One of the show’s strong suits is its portrayal of the capricious ways in which youthful sexuality can express itself: Jay (Jason Mantzoukas), a greasy but sympathetic classmate of Andrew and Nick’s, discovers that he is bisexual by humping a “boy” pillow as well as a “girl” pillow Andrew (John Mulaney), a bespectacled, mustachioed ball of neuroses, develops a crush on his cousin and, although he is ashamed, proceeds to send her a dick pic the lovable, bucktoothed nerd Missy (Jenny Slate) masturbates with her childhood Glo Worm and refers to the act as her “worm dance.” The characters, who, back then, were seventh graders, encountered new growths and protrusions (hard-ons, pubic hair, boobs), distressing secretions (sweat, semen, blood), and the nutso psychological effects these bodily changes incur.

(The tune was originated by Black Sabbath, that band of hormonal lads from Birmingham.) Since 2017, when the first season aired, “Big Mouth” has depicted the riotous, often alarming transformations that puberty wreaks on the young. “I’m going through changes,” Charles Bradley sings in the show’s opening theme. By allowing its characters to age-and by focussing in on them, to an almost painful degree, as they do so-“Big Mouth” can feel more akin to live-action TV than it does to cartoons such as “South Park” and “Bob’s Burgers,” which have used animation to keep their protagonists static over the course of many seasons, as if preserved in amber. That yellow schmuck has been in fourth grade for, like, thirty years.” A clever but heartfelt cartoon that is bursting with pop-cultural references and is popular with adult viewers, “Big Mouth” owes more than a little to “The Simpsons.” (Even the use of “schmuck” is evocative of Krusty the Clown.) Still, Nick’s comment identifies the uniqueness of this series, created by Kroll, Andrew Goldberg, Mark Levin, and Jennifer Flackett. “Look at us, growing up,” Nick (voiced by Nick Kroll) says. An early episode of the fourth season of “Big Mouth,” now streaming on Netflix, opens with the show’s protagonists, Andrew Glouberman and Nick Birch, embarking on their first day of eighth grade.

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